|
KMID : 0545120080180020322
|
|
Journal of Microbiology and Biotechnology
2008 Volume.18 No. 2 p.322 ~ p.327
|
|
|
Production of 1,5-Dihydroxy-3-Methoxy-7-Methylanthracene-9,10-Dione by Submerged Culture of Shiraia bambusicola
|
|
Cai Yujie
Ding Yanrui
Tao Guanjun
Liao Xiangru
|
|
|
Abstract
|
|
|
|
1,5-Dihydroxy-3-methoxy-7-methylanthracene-9,10- dione (shiraiarin) is a kind of antitumor and antibacterial anthraquinone, and was produced for the first time from the submerged fermentation of Shiraia bambusicola, as confirmed by ESI-MS and NMR. The production of shiraiarin was significantly influenced when varying the carbon source, and a high amount of shiraiarin was only achieved when using lactose. The production of shiraiarin was also stimulated when using NaNO3 as the nitrogen source, whereas other nitrogen sources inhibited its production. Shiraiarin was formed during the stationary phase with a pH value higher than 8. The production of shiraiarin was inhibited by sporulation.
|
|
|
KEYWORD
|
|
|
Shiraia bambusicola, shiraiarin, carbon source, nitrogen source, pH
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|